Burkett’s Lymphoma
Burkett’s
lymphoma is an exceedingly rare type of cancer. Less than a thousand cases are
diagnosed yearly in the United States of America.
However,
in some other parts of the world where it is endemic, such as certain parts of
central Africa, Burkett’s lymphoma is very common among children.
Burkett’s
lymphoma is a Non-Hodgkin's Lymphoma (NHL) cancer that affects B lymphocyte
cells. There are 3 distinct varieties of this disease:
-Immunodeficiency-related:
This form of the condition occurs most often in HIV patients and similarly
immunocompromised individuals such as recent transplant recipients. The
condition may signal the onset of AIDS.
-Sporadic:
This variant of the disease is found outside of the African continent. It is
akin to endemic Burkitt's lymphoma and is associated with immune system
compromise.
-Endemic:
This form of the disease is the so-called "African" form and is
responsible for the majority of malignant cases in central African children.
This form of the disease may affect several areas but most often impacts the
jaw, ovaries, breasts, kidneys, facial bone. The Epstein-Barr virus, which is
the virus responsible for mononucleosis is closely associated with Burkett’s.
The
symptoms of Burkett’s lymphoma cancer may include painless, swollen lymph nodes (this
is characteristic of lymphomas in general), hardening and/or rapid growth of
the lymph nodes. Pain in the abdomen is another possible sign.
This
disease can be diagnosed by a variety of modes such as:
-X-ray
of the chest
-Blood Count
-Spinal fluid analysis
-Lymph node and/or bone marrow biopsy
-CT and/or PET scan
-Blood Count
-Spinal fluid analysis
-Lymph node and/or bone marrow biopsy
-CT and/or PET scan
Treatment
of this disease usually involves intense chemotherapy. The earlier that
chemotherapy is started, the better the outlook as this is a particularly
aggressive form of cancer. However, some cancers which grow rapidly such as Burkett’s,
respond more quickly to treatment. This can actually harm the patient through a
process called tumor lyses syndrome, in which the body is subjected to the
byproducts of the breakdown of cancer cells which may cause any of a host of
serious complications such as severe electrolyte disruption and renal failure.
Combination
chemotherapy may be supplemented with radiotherapy, dietary interventions, no
tropics, supplements, exposure to natural sunlight (for vitamin D). Surgery is
often indicated for the removal of tumors and a bone marrow transplant may be
necessary in the case that the bone marrow is affected.
The
prognosis of Burkett’s lymphoma depends upon the risk-factor of the patient. Caught
early (low-risk or low/intermediate risk), combination chemotherapy which has
produced survival rates in the 90% range. These figures decline significantly
for higher risk cases; ~70% for high/intermediate risk and ~30% for high risk.
The total 5 year survival rate for adults with Burkett’s lymphoma is about 50
percent.
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