New T-Cell Treatment May Be a dominant Cancer Fighter:
Researchers
have been working hard to find a way to use the body's own t-cell's to fight
cancer and destroy it. Clinical trials have been conducted and some people who
were participants have gone into complete remission using this exciting and
novel new approach. This is known as "gene therapy" and researchers
have been working furiously for years trying to find ways to utilize the bodies
own cells to be reprogrammed to fight and destroy cancer cells.
A
clinical trial held at The University of Pennsylvania involved providing this
treatment to participants who suffered from leukemia. One participant in
particular, a man who had suffered from leukemia participated in the trial and
it turned his life around for the better. Chemotherapy was no longer effective
for his disease. A few weeks after this treatment, he was in complete remission
with no trace of lymphoma cancer to be found. It is now a year later and he is still
completely cancer free. There were an additional two patients who participated
in this trial. One had another complete remission of the leukemia and the third
participant had a partial remission result. These results are extremely
promising and plans are being made for further gene therapy trials.
The
Procedure: This trial involved the removal of billions of a person's T-cells.
T- Cells are one of the white cells in the human body whose function is to
fight and destroy viruses and tumors. Once these t-cells are removed they are
genetically reprogrammed with new genes. These new genes actually teach the
t-cells to seek out and destroy cancer in the human body. They are then reinvested
back into the patient.
The
doctors who are part of the trial are not stating yet that this is a cure. They
say the treatment is still experimental and has only involved a few patients.
This trial has been written about in The New England Journal of Medicine and
Science Translational Medicine. Many researchers are very excited about it and
feel it is a significant achievement in the field of gene therapy to fight
cancer.
This
procedure basically was able to use a person's own immune system to kill cancer
cells. Researchers are now trying to determine if other types of cancer might
also be responsive to this gene therapy.
The
doctors leading this study and trial said they were also stunned by the results
of complete remission. Although this is still experimental at this point,
researchers hope to replicate this study again and see how it responds to other
types of cancer.
Tumor
Destruction by T-cells: Scientists are trying to determine how to make these
modified t-cells destroy tumors. This particular research study done at The
University of Pennsylvania appears to have been able to accomplish this by
leaving a population of "memory" t-cells" within the body that
will be able to remultiply when needed, as they will recognize the development
of cancerous cells.
This
gene therapy concept of genetically modifying the body's t-cells really began
in the 1980s with research conducted in Israel. Over the years much research
has continued to occur in this area and it appears that scientists are making
great progress. Researchers are hopeful that one day soon, these "cancer killer"
t-cells" will effectively destroy cancer and be available as a therapy
option for people suffering from this dreadful disease.
Potential
Dangers of T-Cell Therapy: Although this research is incredibly promising there
are certain dangers still inherent to it. A person may become venerable to
infection because the treatment will destroy both healthy and cancerous cells
simultaneously, in this leukemia case wiping out a patient's entire B-cell
population. Doctors are providing these patients with precautions such as
periodic infusions of immune building substances to prevent infections from
occurring.
Another
danger could be the overwhelming number of cancer cells that can die off all at
once. This can overwhelm the liver and kidneys and lead to "tumor
lyses", a potentially deadly reaction. Doctors are working on this problem
by providing drugs which will help protect the kidneys while this process is
occurring.
Additionally
there may be other reactions which may be life threatening because everybody is
unique and the modified t-cells can target cancer cells anywhere in the body.
Therefore if there is cancer in the lungs, the lungs may become overwhelmed and
the patient can develop breathing problems which can be dangerous. Additionally
side effect reactions that occur from this treatment include high fevers and
inflammation.
The
Future: Researchers are very excited about the future of genetically modified
t-cell therapy in treating and even destroying cancer. Although it may be years
away, the hope is to perfect the therapy and make it available to anyone who
may benefit from it. Many hurdles still exist including how this treatment
could be massed produced by the pharmaceutical industry. Until that time,
researchers continue to work hard and are grateful for the astonishing results
of complete remission they have already achieved in several patients suffering
from leukemia.
No comments:
Post a Comment