The miracle at regular lymphomas:
Another year has passed, and in a few weeks we celebrated Bureau cancer survivor. When that day comes, I am always, and remember those who have never had the opportunity to celebrate the day.
After practicing medicine for more than three decades as a physician, I was deeply involved in the care of young children. Hospital such as cancer, lymphoma seen my fair share of teething problems. I can say that I like a lot of life with the help of other people in the medical with whom I had worked to save, and of course the latest technologies available, the practice of us who have the privilege of medicine in the United States . Interestingly, the things in life that man to push into education and prepare for the great profession of medicine. One of these things is an event in my childhood in the 1960s.
When I was a child, I had many friends in school and outside of school. He grew up on a ranch in Nebraska, it was not uncommon for a lot of friends who live in other cities come to visit. One of my friends outside of school lived in a nearby town, but often addressed. David and I were eight years. I fond memories of playing "army" with David at the court, and games with him when he came to visit. I liked it. He was friendly and got along well with my sister and my little brother. We were both young, but in different troops. I've always heard how David loved Scouting.
Soon, however, the visitors were always less. David seemed look weak and discolored over time. The color is really bothered me. I asked Mom, "What's wrong with David?" Mom said, "He's sick, honey He has a blood cancer, leukemia is called..." As you can imagine, it was doing a little too difficult for a child of eight years, but with time I've learned more.
David's parents were good friends of my parents, we often like families. After he got sick, we saw less and less of them. Very rare, I got my friend to see. David had a constant condition of weight loss ahead, joint pain, bruising, infection was easily brought to tears, and I thought her hair looked funny. How does a process of eight years, the inevitable demise? As a child, David, her sister, my brother, my sister and I, we were not emotionally mature enough to handle anything.
At home, sometimes I get a call back was in the hospital. My parents were great. If we get these calls, sat mom and dad to do with us and do their best to explain to this thing called leukemia. Understand, this is 1961, and leukemia known as a ruthless murderer of children. There was no cure. Not even a good treatment. The medical community was desperate for a walk.
One evening I received a call from his father David. David died at the age of eight. I remember that it was really the first time I heard those words, "dead." It was the first funeral I went to a friend. Friends should not die when they were children. I take a break and realize that we are mortal. I know I was a child. I saw two grandparents buried, but I was very calm and overcome a lot from this event. All these people I have met strong distribution network began to cry. I have never seen less in a surreal world of sadness, buried good friends of my parents of my friend David .... And this is even more clear .... My friend, who was asleep in his Cub Scout uniform.
The whole time I was there, I remember that David ran behind the plate, but in vain. Why did this happen? I thought I felt a jolt far, "The Calling", many of us are of the "medicine" attracted and trained as a healer and sometimes speak softly.
Time has passed, but I often thought about David and how it was unfair to him and his family. The 1960s were almost all children who had died of leukemia. The survival rate after five years, the children were then only about one in ten. All families who could do was to wait and see, while their babies died in agony. He never had a chance, which often included. A nice boy, separated from his family at a young age. He never had the chance to do something after he became ill. There was never an Eagle Scout, baseball game, is it cool at school, or fall in love. It must have been scared.
Term and in high school, I did not hear about some progress in the fight against cancer and leukemia. Then, in the 1970s, when I was a graduate student in chemistry, we started to hear about a new drug, a very promising drug in the fight against leukemia. Leukemia cells killed access their ability to frolic acid to treat for the synthesis of DNA. Called Merthiolate, I remember myself thinking .... Damn it! A little late, but less than ten years ago came with a firearm.
I grew up with kids who have had polio, but now it's gone. Diphtheria is gone. Smallpox was almost defeated. Hospitals have been replaced by more advanced narcolepsy drugs, allowing patients before they integrate into society and become productive citizens. They had invented the CAT scan. They started to use lasers in ophthalmology. And I think barking is even transplanted heart William Denton Cooley in Texas of all places! Things really happened, and I did not want to be out there inside. It was a revelation. You are a man of science, I realized that I become a doctor.
Over time many have seen this ant metabolite drugs available and we found a real gap in infant mortality from leukemia. Shortly after the end of the year 1970, when I. Biochemist and begin my career in medicine, a drug made from a flower called "Evergreen", which only grows in the rain forests of Madagascar (go figure) gave us a new drug called Cristine A drug that can be prepared in the kitchen of Mother Nature, it was a monumental discovery. Never before have we been in a position, a drug that hold mitosis in cancer cells directly by the closure of its ability to cross the phosphatase. Thus, Cristine and inelastic destroy sister micro tubule so that the cells do not PIN leads to an inability to procreate.
Then when I was a junior doctor, has found a way to bone marrow transplants, cancer cells precursors white exchange fees discovered normal white blood cells. You guessed it. We saw not only cures and remissions. Now lives saved in this war.
David had, my friend, what we do. "Acute leukemia" as There are several types of leukemia, leukemia, but two, is known to prey on children. There is acute lymphoblastic leukemia, ALL, David had, which usually tries her two children aged ten and acute myeloid leukemia, AML, which usually tries, baby year, less than 1.
Acute leukemia tumor proliferation of progenitor cells in the bone marrow cancer cells immature white phase explosion. Healthy cells do not function as white blood cells to fight infections. Multiply violent havoc on the body literally consume the patient's death, a so-called "cachexia". Patients have severe bone pain, anemia, infections, swollen lymph nodes, spleen and liver, and for some, failure, meningitis, strokes, heart attacks and kidney. Without treatment, those who died within a few weeks to a few months.
We still have a thorough knowledge of its cause. Most disturbing are mutated through ontogeny, the cancer gene encodes for the programming and development of cancer programmed cell death called "apoptosis" causes. What is the cause, is it scratched his head. Many of us think that it is exposure to radiation or certain viruses. Perhaps environmental toxins or radioactive cosmic explosions. And of course, the man suspected toxins are obvious.
In spring 1990 we were seen cure rates in both ALL and AML and 50 percent remission rates of about 80 percent. Which jump? In just three decades a paradigm shift in the treatment and the results of our children with leukemia, on the other hand, guarantees seen a change in the treatment, which uses a team approach in order to protect our children from depression and acute diseases, that these terrible accompany diseases.
New drugs such as daunorubicin have accelerated these therapies for even better results. Although this drug is very effective, is extremely toxic and cardio usually not used in children. However, it should be noted that we are now seeing 95 percent remission rate and 60 percent cure rate for our children with ALL and AML, a real change in mortality that are not dreamed of 35 years.
Methotrexate is the headquarters for the treatment of leukemia, and in combination with other medicines. Unfortunately, there has been a recent shortage of medicines to the decline in production, drug companies and ask for more money and charge exorbitant prices. It is a practice unethical and shameful in my opinion. We have tried. A lot of press lately hopefully this will change our campaigns and lobbying to keep production costs will be successful.
But now, the treatments on the horizon for leukemia? There is a new drug. This drug has hit the shelves of cancer chemotherapy ten years ago, but it looks promising exceptional, even outside of the treatment of cancer. Mainly for chronic myeloid leukemia, CML used leukemia is usually seen in older people is very effective. Ontogenetic code representation for the induction of cancer cell death in their tracks is a drug target is addressed led to a lack of specific chromosomal translocation in over 90% of patients with CML, called the Philadelphia chromosome. The drug, Imagine, was built by a rational drug design to biochemical research in force in relation to the specific allele codes Philadelphia chromosome base, and ends with the production of a protein called tyrosine kina inducing distribution cancerous white blood cells that normally to function.
Used was thought of as a treatment for leukemia is another, including lymphocytic leukemia and acute chronic myeloproliferative diseases (cancer of the bone marrow is usually seen in the elderly) with great success. But what is also very interesting experimental applications are considered.
Imagine is used as a treatment for pulmonary hypertension, fulminate form of high blood pressure in the lungs has been announced. It has been shown to reduce information is called smooth muscle hypertrophy and hyperplasia of the pulmonary vascular tree. In systemic sclerosis, the drug for potential use in delayed pulmonary fibrosis was tested. In addition, current laboratory promising to stop the progression of atherosclerotic vascular disease in mice. Yes, a treatment of coronary artery disease and myocardial infarction.
At Emory University in Atlanta, there are some promising studies that they can beat imagine are used as antiviral against smallpox. Why is this important? Although the disease has been eradicated from the face of the earth with the remarkable efforts of the World Health Organization, and no cases have been identified in almost thirty years, we continue to believe that some form of possible smallpox weapon zed a rogue state.
Present studies suggest that a modified protein can bind to increase the production and accumulation of amyloidal plaques in Alzheimer's disease, making it inert. Yes, a treatment for the disease induced dementia Alzheimer's disease.
But with all of this in our medicine bags, there is still the specter of dark and creepy. Although great progress has been made, and I had the privilege of knowing and caring for children with leukemia, and even to overcome the disease and focus on their lives, is a patient.
I worked in the emergency room one night in 1995. It was relatively quiet in the night, when about two-clock in the morning, a man walked in carrying out your teen. We moved quickly and helped her son on a stretcher in an open bay.
The staff and I immediately recognized the man as the son of Eric, a school famous football star. The father said he found his son on the floor trying to crawl into the kitchen to fetch a glass of water. Eric was terrible. It was that damn color again. Eric was delirious to respond with fever, weak and poor. We started working on it immediately. His father said it was fine a month ago, but had developed a sore throat at the time, and saw one of our local doctors so that antibiotics. We managed to get Eric Young stabilized. Just as you settle in and to his father at home, I received a call from the lab. The lab has asked me to go to the lab. I ran into the laboratory. When I arrived, the technology was shaking his head, as if to say: I looked at the machine screen blood "This is really bad.” "My God," I said to the technology. "His white blood cell count is 60,000." I looked into the microscope "blasts". I knew immediately that we are looking at a type of acute leukemia could not recognize.
As I walked into the emergency room, Eric was a little. I talked to him and assured him. However, could the expression on my face, as he turned his father do not disappear? He knew I was not good news. We talked at length, because I called Eric GP. They spoke as the team and I continue to work on Eric. I called the helicopter, told his colleagues Hematology at the University, and Eric returned to his father, made sure we knew what we were doing and they both flew to the University Hospital. All eyes turned to the Oncology Hematology, hoping that might help young Eric.
A week later, "ceased to exist" the patients in my practice, called the hematology department of the university, to tell me that Eric had. You sit yourself and learn introspection when these things sting like a healer. I asked myself. How robust young athlete falls ill with leukemia, health fail as quickly and dies within a month? As it turned out, Eric commissioned a form of AML called promyelocytic leukemia, one of the deadliest forms of AML that feeds on young children, and take out the back door and speed. As you can see, our work is not finished. It reminds me of why we do a "practice" name.
Our knowledge of the genome, stem cell technology, ontogenetic race of nanotechnology. Our ability to rational drug design is exceptional and technical know-how to produce these great magic potions is nothing short of a miracle. Within four decades, we have almost crashed the disease that killed my friend, David. But as you can see with Eric, we have not done yet. I still think David 50 years later, and what stirred his death in a child, the spark to become a doctor. If I was polite, but just to save a human life, it was worth it.
We have at our disposal two technologies should be implemented. Stem cell research we have the opportunity to override the murderer, and should never be interrupted. Responsible and the science of manipulating ontogeny fuel, these diseases feeds are now available. My hope is that with our new technologies in the near future we will not need drugs for leukemia. Simply disable the genetic mechanism of cancer of the bone marrow and leukemia did not exist, and therefore never again threaten our children.
Lymphoma miracle standards
Another year has passed, and in a few weeks we celebrated Bureau cancer survivor. When that day comes, I am always, and remember those who have never had the opportunity to celebrate the day.
After practicing medicine for more than three decades as a physician, I was deeply involved in the care of young children. Hospital such as cancer, lymphoma seen my fair share of teething problems. I can say that I like a lot of life with the help of other people in the medical with whom I had worked to save, and of course the latest technologies available, the practice of us who have the privilege of medicine in the United States . Interestingly, the things in life that man to push into education and prepare for the great profession of medicine. One of these things is an event in my childhood in the 1960s.
When I was a child, I had many friends in school and outside of school. He grew up on a ranch in Nebraska, it was not uncommon for a lot of friends who live in other cities come to visit. One of my friends outside of school lived in a nearby town, but often addressed. David and I were eight years. I fond memories of playing "army" with David at the court, and games with him when he came to visit. I liked it. He was friendly and got along well with my sister and my little brother. We were both young, but in different troops. I've always heard how David loved Scouting.
Soon, however, the visitors were always less. David seemed look weak and discolored over time. The color is really bothered me. I asked Mom, "What's wrong with David?" Mom said, "He's sick, honey He has a blood cancer, leukemia is called..." As you can imagine, it was doing a little too difficult for a child of eight years, but with time I've learned more.
David's parents were good friends of my parents, we often like families. After he got sick, we saw less and less of them. Very rare, I got my friend to see. David had a constant condition of weight loss ahead, joint pain, bruising, infection was easily brought to tears, and I thought her hair looked funny. How does a process of eight years, the inevitable demise? As a child, David, her sister, my brother, my sister and I, we were not emotionally mature enough to handle anything.
At home, sometimes I get a call back was in the hospital. My parents were great. If we get these calls, sat mom and dad to do with us and do their best to explain to this thing called leukemia. Understand, this is 1961, and leukemia known as a ruthless murderer of children. There was no cure. Not even a good treatment. The medical community was desperate for a walk.
One evening I received a call from his father David. David died at the age of eight. I remember that it was really the first time I heard those words, "dead." It was the first funeral I went to a friend. Friends should not die when they were children. I take a break and realize that we are mortal. I know I was a child. I saw two grandparents buried, but I was very calm and overcome a lot from this event. All these people I have met strong distribution network began to cry. I have never seen less in a surreal world of sadness, buried good friends of my parents of my friend David .... And this is even more clear .... My friend, who was asleep in his Cub Scout uniform.
The whole time I was there, I remember that David ran behind the plate, but in vain. Why did this happen? I thought I felt a jolt far, "The Calling", many of us are of the "medicine" attracted and trained as a healer and sometimes speak softly.
Time has passed, but I often thought about David and how it was unfair to him and his family. The 1960s were almost all children who had died of leukemia. The survival rate after five years, the children were then only about one in ten. All families who could do was to wait and see, while their babies died in agony. He never had a chance, which often included. A nice boy, separated from his family at a young age. He never had the chance to do something after he became ill. There was never an Eagle Scout, baseball game, is it cool at school, or fall in love. It must have been scared.
Term and in high school, I did not hear about some progress in the fight against cancer and leukemia. Then, in the 1970s, when I was a graduate student in chemistry, we started to hear about a new drug, a very promising drug in the fight against leukemia. Leukemia cells killed access their ability to frolic acid to treat for the synthesis of DNA. Called Merthiolate, I remember myself thinking .... Damn it! A little late, but less than ten years ago came with a firearm.
I grew up with kids who have had polio, but now it's gone. Diphtheria is gone. Smallpox was almost defeated. Hospitals have been replaced by more advanced narcolepsy drugs, allowing patients before they integrate into society and become productive citizens. They had invented the CAT scan. They started to use lasers in ophthalmology. And I think barking is even transplanted heart William Denton Cooley in Texas of all places! Things really happened, and I did not want to be out there inside. It was a revelation. You are a man of science, I realized that I become a doctor.
Over time many have seen this ant metabolite drugs available and we found a real gap in infant mortality from leukemia. Shortly after the end of the year 1970, when I. Biochemist and begin my career in medicine, a drug made from a flower called "Evergreen", which only grows in the rain forests of Madagascar (go figure) gave us a new drug called Cristine A drug that can be prepared in the kitchen of Mother Nature, it was a monumental discovery. Never before have we been in a position, a drug that hold mitosis in cancer cells directly by the closure of its ability to cross the phosphatase. Thus, Cristine and inelastic destroy sister micro tubule so that the cells do not PIN leads to an inability to procreate.
Then when I was a junior doctor, has found a way to bone marrow transplants, cancer cells precursors white exchange fees discovered normal white blood cells. You guessed it. We saw not only cures and remissions. Now lives saved in this war.
David had, my friend, what we do. "Acute leukemia" as There are several types of leukemia, leukemia, but two, is known to prey on children. There is acute lymphoblastic leukemia, ALL, David had, which usually tries her two children aged ten and acute myeloid leukemia, AML, which usually tries, baby year, less than 1.
Acute leukemia tumor proliferation of progenitor cells in the bone marrow cancer cells immature white phase explosion. Healthy cells do not function as white blood cells to fight infections. Multiply violent havoc on the body literally consume the patient's death, a so-called "cachexia". Patients have severe bone pain, anemia, infections, swollen lymph nodes, spleen and liver, and for some, failure, meningitis, strokes, heart attacks and kidney. Without treatment, those who died within a few weeks to a few months.
We still have a thorough knowledge of its cause. Most disturbing are mutated through ontogeny, the cancer gene encodes for the programming and development of cancer programmed cell death called "apoptosis" causes. What is the cause, is it scratched his head. Many of us think that it is exposure to radiation or certain viruses. Perhaps environmental toxins or radioactive cosmic explosions. And of course, the man suspected toxins are obvious.
In spring 1990 we were seen cure rates in both ALL and AML and 50 percent remission rates of about 80 percent. Which jump? In just three decades a paradigm shift in the treatment and the results of our children with leukemia, on the other hand, guarantees seen a change in the treatment, which uses a team approach in order to protect our children from depression and acute diseases, that these terrible accompany diseases.
New drugs such as daunorubicin have accelerated these therapies for even better results. Although this drug is very effective, is extremely toxic and cardio usually not used in children. However, it should be noted that we are now seeing 95 percent remission rate and 60 percent cure rate for our children with ALL and AML, a real change in mortality that are not dreamed of 35 years.
Methotrexate is the headquarters for the treatment of leukemia, and in combination with other medicines. Unfortunately, there has been a recent shortage of medicines to the decline in production, drug companies and ask for more money and charge exorbitant prices. It is a practice unethical and shameful in my opinion. We have tried. A lot of press lately hopefully this will change our campaigns and lobbying to keep production costs will be successful.
But now, the treatments on the horizon for leukemia? There is a new drug. This drug has hit the shelves of cancer chemotherapy ten years ago, but it looks promising exceptional, even outside of the treatment of cancer. Mainly for chronic myeloid leukemia, CML used leukemia is usually seen in older people is very effective. Ontogenetic code representation for the induction of cancer cell death in their tracks is a drug target is addressed led to a lack of specific chromosomal translocation in over 90% of patients with CML, called the Philadelphia chromosome. The drug, Imagine, was built by a rational drug design to biochemical research in force in relation to the specific allele codes Philadelphia chromosome base, and ends with the production of a protein called tyrosine kina inducing distribution cancerous white blood cells that normally to function.
Used was thought of as a treatment for leukemia is another, including lymphocytic leukemia and acute chronic myeloproliferative diseases (cancer of the bone marrow is usually seen in the elderly) with great success. But what is also very interesting experimental applications are considered.
Imagine is used as a treatment for pulmonary hypertension, fulminate form of high blood pressure in the lungs has been announced. It has been shown to reduce information is called smooth muscle hypertrophy and hyperplasia of the pulmonary vascular tree. In systemic sclerosis, the drug for potential use in delayed pulmonary fibrosis was tested. In addition, current laboratory promising to stop the progression of atherosclerotic vascular disease in mice. Yes, a treatment of coronary artery disease and myocardial infarction.
At Emory University in Atlanta, there are some promising studies that they can beat imagine are used as antiviral against smallpox. Why is this important? Although the disease has been eradicated from the face of the earth with the remarkable efforts of the World Health Organization, and no cases have been identified in almost thirty years, we continue to believe that some form of possible smallpox weapon zed a rogue state.
Present studies suggest that a modified protein can bind to increase the production and accumulation of amyloidal plaques in Alzheimer's disease, making it inert. Yes, a treatment for the disease induced dementia Alzheimer's disease.
But with all of this in our medicine bags, there is still the specter of dark and creepy. Although great progress has been made, and I had the privilege of knowing and caring for children with leukemia, and even to overcome the disease and focus on their lives, is a patient.
I worked in the emergency room one night in 1995. It was relatively quiet in the night, when about two-clock in the morning, a man walked in carrying out your teen. We moved quickly and helped her son on a stretcher in an open bay.
The staff and I immediately recognized the man as the son of Eric, a school famous football star. The father said he found his son on the floor trying to crawl into the kitchen to fetch a glass of water. Eric was terrible. It was that damn color again. Eric was delirious to respond with fever, weak and poor. We started working on it immediately. His father said it was fine a month ago, but had developed a sore throat at the time, and saw one of our local doctors so that antibiotics. We managed to get Eric Young stabilized. Just as you settle in and to his father at home, I received a call from the lab. The lab has asked me to go to the lab. I ran into the laboratory. When I arrived, the technology was shaking his head, as if to say: I looked at the machine screen blood "This is really bad.” "My God," I said to the technology. "His white blood cell count is 60,000." I looked into the microscope "blasts". I knew immediately that we are looking at a type of acute leukemia could not recognize.
As I walked into the emergency room, Eric was a little. I talked to him and assured him. However, could the expression on my face, as he turned his father do not disappear? He knew I was not good news. We talked at length, because I called Eric GP. They spoke as the team and I continue to work on Eric. I called the helicopter, told his colleagues Hematology at the University, and Eric returned to his father, made sure we knew what we were doing and they both flew to the University Hospital. All eyes turned to the Oncology Hematology, hoping that might help young Eric.
A week later, "ceased to exist" the patients in my practice, called the hematology department of the university, to tell me that Eric had. You sit yourself and learn introspection when these things sting like a healer. I asked myself. How robust young athlete falls ill with leukemia, health fail as quickly and dies within a month? As it turned out, Eric commissioned a form of AML called promyelocytic leukemia, one of the deadliest forms of AML that feeds on young children, and take out the back door and speed. As you can see, our work is not finished. It reminds me of why we do a "practice" name.
Our knowledge of the genome, stem cell technology, ontogenetic race of nanotechnology. Our ability to rational drug design is exceptional and technical know-how to produce these great magic potions is nothing short of a miracle. Within four decades, we have almost crashed the disease that killed my friend, David. But as you can see with Eric, we have not done yet. I still think David 50 years later, and what stirred his death in a child, the spark to become a doctor. If I was polite, but just to save a human life, it was worth it.
We have at our disposal two technologies should be implemented. Stem cell research we have the opportunity to override the murderer, and should never be interrupted. Responsible and the science of manipulating ontogeny fuel, these diseases feeds are now available. My hope is that with our new technologies in the near future we will not need drugs for leukemia. Simply disable the genetic mechanism of cancer of the bone marrow and leukemia did not exist, and therefore never again threaten our children.
Lymphoma miracle standards
No comments:
Post a Comment