The widespread
phenomenon in lymphoma:
Another year has passed, and in a few
weeks we celebrated Bureau cancer survivor. When that day comes, I am always,
and remember those who have never had the opportunity to celebrate the day.
After practicing medicine for more than
three decades as a physician, I was deeply involved in the care of young
children. Hospital such as cancer, lymphoma seen my fair share of teething
problems. I can say that I like a lot of life with the help of other people in
the medical with whom I had worked to save, and of course the latest
technologies available, the practice of us who have the privilege of medicine
in the United States . Interestingly, the things in life that man to push into
education and prepare for the great profession of medicine. One of these things
is an event in my childhood in the 1960s.
When I was a child, I had many friends
in school and outside of school. He grew up on a ranch in Nebraska, it was not
uncommon for a lot of friends who live in other cities come to visit. One of my
friends outside of school lived in a nearby town, but often addressed. David
and I were eight years. I fond memories of playing "army" with David
at the court, and games with him when he came to visit. I liked it. He was
friendly and got along well with my sister and my little brother. We were both
young, but in different troops. I've always heard how David loved Scouting.
Soon, however, the visitors were always
less. David seemed look weak and discolored over time. The color is really
bothered me. I asked Mom, "What's wrong with David?" Mom said,
"He's sick, honey He has a blood cancer, leukemia is called..." As
you can imagine, it was doing a little too difficult for a child of eight
years, but with time I've learned more.
David's parents were good friends of my
parents, we often like families. After he got sick, we saw less and less of
them. Very rare, I got my friend to see. David had a constant condition of
weight loss ahead, joint pain, bruising, infection was easily brought to tears,
and I thought her hair looked funny. How does a process of eight years, the
inevitable demise? As a child, David, her sister, my brother, my sister and I,
we were not emotionally mature enough to handle anything.
At home, sometimes I get a call back was
in the hospital. My parents were great. If we get these calls, sat mom and dad
to do with us and do their best to explain to this thing called leukemia.
Understand, this is 1961, and leukemia known as a ruthless murderer of
children. There was no cure. Not even a good treatment. The medical community
was desperate for a walk.
One evening I received a call from his
father David. David died at the age of eight. I remember that it was really the
first time I heard those words, "dead." It was the first funeral I
went to a friend. Friends should not die when they were children. I take a
break and realize that we are mortal. I know I was a child. I saw two
grandparents buried, but I was very calm and overcome a lot from this event.
All these people I have met strong distribution network began to cry. I have
never seen less in a surreal world of sadness, buried good friends of my
parents of my friend David.... And this is even clearer.... My friend, who was
asleep in his Cub Scout uniform.
The whole time I was there, I remember
that David ran behind the plate, but in vain. Why did this happen? I thought I
felt a jolt far, "The Calling", many of us are of the
"medicine" attracted and trained as a healer and sometimes speak
softly.
Time has passed, but I often thought
about David and how it was unfair to him and his family. The 1960s were almost
all children who had died of leukemia. The survival rate after five years, the
children were then only about one in ten. All families who could do were to
wait and see, while their babies died in agony. He never had a chance, which
often included. A nice boy, separated from his family at a young age. He never
had the chance to do something after he became ill. There was never an Eagle
Scout, baseball game, is it cool at school, or fall in love. It must have been
scared.
Term and in high school, I did not hear
about some progress in the fight against cancer and leukemia. Then, in the
1970s, when I was a graduate student in chemistry, we started to hear about a
new drug, a very promising drug in the fight against leukemia. Leukemia cells
killed access their ability to folic acid to treat for the synthesis of DNA.
Called methotrexate, I remember myself thinking.... Damn it! A little late, but
less than ten years ago came with a firearm.
I grew up with kids who have had polio,
but now it's gone. Diphtheria is gone. Smallpox was almost defeated. Hospitals
have been replaced by more advanced narcolepsy drugs, allowing patients before
they integrate into society and become productive citizens. They had invented
the CAT scan. They started to use lasers in ophthalmology. And I think barking
is even transplanted heart William Denton Cooley in Texas of all places! Things
really happened, and I did not want to be out there inside. It was a
revelation. You are a man of science; I realized that I become a doctor.
Over time many have seen this ant
metabolite drugs available and we found a real gap in infant mortality from
leukemia. Shortly after the end of the year 1970, when I. Biochemist and begin
my career in medicine, a drug made from a flower called "Evergreen", which
only grows in the rain forests of Madagascar (go figure) gave us a new drug
called vincristine A drug that can be prepared in the kitchen of Mother Nature,
it was a monumental discovery. Never before have we been in a position, a drug
that hold mitosis in cancer cells directly by the closure of its ability to
cross the telophase. Thus, vincristine and vinblastine destroy sister
microtubule so that the cells do not PIN leads to an inability to procreate.
Then when I was a junior doctor, has
found a way to bone marrow transplants, cancer cells precursors white exchange
fees discovered normal white blood cells. You guessed it. We saw not only cures
and remissions. Now lives saved in this war.
David had, my friend, what we do.
"Acute leukemia" as There are several types of leukemia, leukemia,
but two, is known to prey on children. There is acute lymphoblastic leukemia,
ALL, David had, which usually tries her two children aged ten and acute myeloid
leukemia, AML, which usually tries, baby year, less than 1.
Acute leukemia tumor proliferation of
progenitor cells in the bone marrow cancer cells immature white phase
explosion. Healthy cells do not function as white blood cells to fight
infections. Multiply violent havoc on the body literally consume the patient's
death, a so-called "cachexia". Patients have severe bone pain,
anemia, infections, swollen lymph nodes, spleen and liver, and for some,
failure, meningitis, strokes, heart attacks and kidney. Without treatment,
those who died within a few weeks to a few months.
We still have a thorough knowledge of
its cause. Most disturbing is mutated through ontogeny, the cancer gene encodes
for the programming and development of cancer programmed cell death called
"apoptosis" causes. What is the cause is it scratched his head. Many
of us think that it is exposure to radiation or certain viruses. Perhaps
environmental toxins or radioactive cosmic explosions. And of course, the man
suspected toxins are obvious.
In spring 1990 we were seen cure rates
in both ALL and AML and 50 percent remission rates of about 80 percent. Which jump?
In just three decades a paradigm shift in the treatment and the results of our
children with leukemia, on the other hand, guarantees seen a change in the
treatment, which uses a team approach in order to protect our children from
depression and acute diseases, that these terrible accompany diseases.
New drugs such as daunorubicin have
accelerated these therapies for even better results. Although this drug is very
effective, is extremely toxic and cardio usually not used in children. However,
it should be noted that we are now seeing 95 percent remission rate and 60
percent cure rate for our children with ALL and AML, a real change in mortality
that are not dreamed of 35 years.
Methotrexate is the headquarters for the
treatment of leukemia, and in combination with other medicines. Unfortunately,
there has been a recent shortage of medicines to the decline in production,
drug companies and ask for more money and charge exorbitant prices. It is a
practice unethical and shameful in my opinion. We have tried. A lot of press
lately hopefully this will change our campaigns and lobbying to keep production
costs will be successful.
But now, the treatments on the horizon
for leukemia? There is a new drug. This drug has hit the shelves of cancer
chemotherapy ten years ago, but it looks promising exceptional, even outside of
the treatment of cancer. Mainly for chronic myeloid leukemia, CML used leukemia
is usually seen in older people is very effective. Ontogenetic code representation
for the induction of cancer cell death in their tracks is a drug target is
addressed led to a lack of specific chromosomal translocation in over 90% of
patients with CML, called the Philadelphia chromosome. The drug, Imagine, was
built by a rational drug design to biochemical research in force in relation to
the specific allele codes Philadelphia chromosome base, and ends with the
production of a protein called tyrosine kina inducing distribution cancerous
white blood cells that normally to function.
Used was thought of as a treatment for
leukemia is another, including lymphocytic leukemia and acute chronic
myeloproliferative diseases (cancer of the bone marrow is usually seen in the
elderly) with great success. But what is also very interesting experimental
applications are considered.
Imagine is used as a treatment for
pulmonary hypertension, fulminant form of high blood pressure in the lungs has
been announced. It has been shown to reduce information is called smooth muscle
hypertrophy and hyperplasia of the pulmonary vascular tree. In systemic
sclerosis, the drug for potential use in delayed pulmonary fibrosis was tested.
In addition, current laboratory promising to stop the progression of
atherosclerotic vascular disease in mice. Yes, a treatment of coronary artery
disease and myocardial infarction.
At Emory University in Atlanta, there
are some promising studies that they can beat imagine are used as antiviral
against smallpox. Why is this important? Although the disease has been
eradicated from the face of the earth with the remarkable efforts of the World
Health Organization, and no cases have been identified in almost thirty years,
we continue to believe that some form of possible smallpox weapon zed a rogue
state.
Present studies suggest that a modified
protein can bind to increase the production and accumulation of amyloidal
plaques in Alzheimer's disease, making it inert. Yes, a treatment for the
disease induced dementia Alzheimer's disease.
But with all of this in our medicine
bags, there is still the specter of dark and creepy. Although great progress
has been made, and I had the privilege of knowing and caring for children with
leukemia, and even to overcome the disease and focus on their lives, is a
patient.
I worked in the emergency room one night
in 1995. It was relatively quiet in the night, when about two-clock in the
morning, a man walked in carrying out your teen. We moved quickly and helped
her son on a stretcher in an open bay.
The staff and I immediately recognized
the man as the son of Eric, a school famous football star. The father said he
found his son on the floor trying to crawl into the kitchen to fetch a glass of
water. Eric was terrible. It was that damn color again. Eric was delirious to
respond with fever, weak and poor. We started working on it immediately. His father
said it was fine a month ago, but had developed a sore throat at the time, and
saw one of our local doctors so that antibiotics. We managed to get Eric Young
stabilized. Just as you settle in and to his father at home, I received a call
from the lab. The lab has asked me to go to the lab. I ran into the laboratory.
When I arrived, the technology was shaking his head, as if to say: I looked at
the machine screen blood "This is really bad.” "My God," I said
to the technology. "His white blood cell count is 60,000." I looked
into the microscope "blasts". I knew immediately that we are looking
at a type of acute leukemia could not recognize.
As I walked into the emergency room,
Eric was a little. I talked to him and assured him. However, could the expression
on my face, as he turned his father do not disappear? He knew I was not good
news. We talked at length, because I called Eric GP. They spoke as the team and
I continue to work on Eric. I called the helicopter, told his colleagues
Hematology at the University, and Eric returned to his father, made sure we
knew what we were doing and they both flew to the University Hospital. All eyes
turned to the Oncology Hematology, hoping that might help young Eric.
A week later, "ceased to
exist" the patients in my practice, called the hematology department of
the university, to tell me that Eric had. You sit yourself and learn
introspection when these things sting like a healer. I asked myself. How robust
young athlete falls ill with leukemia, health fail as quickly and dies within a
month? As it turned out, Eric commissioned a form of AML called promyelocytic
leukemia, one of the deadliest forms of AML that feeds on young children, and
take out the back door and speed. As you can see, our work is not finished. It
reminds me of why we do a "practice" name.
Our knowledge of the genome, stem cell
technology, ontogenetic race of nanotechnology. Our ability to rational drug
design is exceptional and technical know-how to produce these great magic
potions is nothing short of a miracle. Within four decades, we have almost crashed
the disease that killed my friend, David. But as you can see with Eric, we have
not done yet. I still think David 50 years later, and what stirred his death in
a child, the spark to become a doctor. If I was polite, but just to save a
human life, it was worth it.
We have at our disposal two technologies
should be implemented. Stem cell research we have the opportunity to override
the murderer, and should never be interrupted. Responsible and the science of
manipulating ontogeny fuel, these diseases feeds are now available. My hope is
that with our new technologies in the near future we will not need drugs for
leukemia. Simply disable the genetic mechanism of cancer of the bone marrow and
leukemia did not exist, and therefore never again threaten our children.
Lymphoma miracle standards
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